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 Chlorambucil Brand name:- Leukeran 2,5 mg tab. Chlorambucil is a very slow acting alkylating agent, especially active on lymphoid tissue: Myeloid tissue is largely spared. It is the drug of choice for long- trem maintenance therapy for chronic lymphatic leukaemia; non - Hodgkin lymphoma and few solid tumors also resolve. It has some immunosuppressant property. Pharmacodynamic:-  Chlorambucil is an antineoplastic in the class of alkylating agents that is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhi...