BENZTHIAZIDE BRAND NAME:- Aquatag, Dihydrex, Diucen, Edemax, Exna, Foven. BENZTHIAZIDE is a diuretic medicine, used alone or in combination with other medicines to treat high blood pressure and edema (swelling). It should be used with caution in patients with severe kidney disease. Frequent monitoring of blood pressure and electrolytes level is necessary while taking this medicine. PHARMACODYNAMIC:- BENZTHIAZIDE promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conduct...
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