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 ADEFOVIR DIPIVOXIL BRAND NAME:- ADESERA ,ADEFOVIR 10mg tab. ADEFOVIR DIPIVOXIL is an anti-hepatitis virus / nonselective antiviral drug and adefovir is a monophosphate analogue of AMP which is active against HBV and some other DNA as well as RNA virus. ABSORPTION & MECHANISM & PHARMACOLOGICAL ACTIONS:-  ADEFOVIR is a monophosphate analogue of AMP which is active against HBV and some other DNA 🧬 as well as RNA viruses,but is used only for hepatitis caused by HBV. Esterases in the intestine and liver release the active drug during absorption to attain oral bioavailability of - 60% in terms of adefovir, which is then distributed in whole body water . On entering cells, adefovir is phosphorylated to the diphosphate which has high affinity for HBV DNA polymerase compared to host cell DNA polymerase.   Ths is enzyme is inhibited and adefovir itself gets incorporated in the viral DNA resulting in termination of the DNA chain . adefovir is primarily excerted by the kidn...