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 BACLOFEN BRAND NAME :- Lioresal ,liofen 10mg ,25mg tab . BACLOFEN is a commonly used muscle relaxer for the treatment of muscle spasms. It can be helpful for people with multiple sclerosis or spinal cord problems. Baclofen is available as oral tablets, granules, and liquid solutions. PHARMACODYNAMIC:-  Chemically, baclofen is a derivative of the neurotransmitter γ-aminobutyric acid (GABA). It is believed to work by activating (or agonizing) GABA receptors, specifically the GABAB receptors.[23] Its beneficial effects in spasticity result from its actions in the brain and spinal cord. PHARMACOKINETICS:-  The drug is rapidly absorbed after oral administration and is widely distributed throughout the body. Biotransformation is low: the drug is predominantly excreted unchanged by the kidneys.The half-life of baclofen is roughly 2–4 hours; it therefore needs to be administered frequently throughout the day to control spasticity appropriately. PHARMACODYNAMIC:-  Baclofen i...