ACETOMENAPHTHONE (VITAMIN K3) FAT SOLUBLE BRAND NAME:-ACETOMENADIONE 5,10mg tab; KAPILIN 10mg tab. ACETOMENAPHTHONE is a fat soluble dietary principal for the synthesis of clotting factors, which promote coagulation and are indicated in haemorrhagic states. CHEMISTRY AND SOURCE:- Vit K has a basic naphthoquinone structure, with or without a side chain (R) at position 3. The side chain in K1 is phytyl ,in K2 prenyl , while in K3 there is no side chain. ACTION:- VITAMIN K3 acts as a cofactor at a late stage in the synthesis by liver of coagulation protein — prothrombin, factors VII,IX and X. The vit K dependent change (y carboxylation of glutamate residues of these zymogen proteins; confers on them the capacity to bind Ca2+ and to get bound to phospholipids surface — properties essential for participation in the coagulation cascade. UTILISATION:- Fat- soluble froms of vit K are absorbed from the intestine via lymph and require bile salts for absorption, while water soluble froms are...
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