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Cefixime Uses, Side Effects, and More

 Cefixime

Brand name:- Topcef, orfix 100,200mgtab/ cap, cefspan ,Taxim- o ,zifi tab.

Cefixime is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

Pharmacodynamic:-

Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.

 Mechanism of action:- 

The bactericidal action of Cefixime is due to the inhibition of cell wall synthesis. It binds to one of the penicillin binding proteins (PBPs) which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption Only 40–50% is absorbed from the GI tract (oral bioavailability). Absorption may be slowed but not decreased when taken with food. Average peak concentration after administration of oral suspension is approximately 25–50% greater than the peak concentration following oral tablet or capsules administration.
Distribution It has high concentrations in bile and urine. It can cross the placenta and its protein binding capacity is 65%.
It is always better to perform appropriate cultures and susceptibility studies to determine the causative organism and its sensitivity to cefixime


used:-

used to treat a number of bacterial infections.These infections include otitis media, strep throat, pneumonia, urinary tract infections, gonorrhea, and Lyme disease.For gonorrhea typically only one dose is required.


 Side effects:- 

Nausea, Diarrhea, Vomiting, Loose stools, Flatulence, Abdominal pain, Dyspepsia.

Dose:- 200-400mg BD, as directed by your doctor.

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