CLARITHROMYCIN Uses, Side Effects, and More

 CLARITHROMYCIN 

BRAND NAME :- CLARIBID ,CLAIMAC, SYNCLAR 

ClARITHROMYCIN is an antibiotic. It works by preventing synthesis of essential proteins required by bacteria to carry out vital functions. Thus, it stops the bacteria from growing, and prevents the infection from spreading.

Pharmacodyanimcs:- 

Clarithromycin is a macrolide antibiotic whose spectrum of activity includes many gram-positive (Staphylococcus aureus, S. pneumoniae, and S. pyogenes) and gram-negative aerobic bacteria (Haemophilus influenzae, H. parainfluenzae, and Moraxella catarrhalis), many anaerobic bacteria, some mycobacteria, and some other organisms including Mycoplasma, Ureaplasma, Chlamydia, Toxoplasma, and Borrelia. Other aerobic bacteria that clarithromycin has activity against include C. pneumoniae and M. pneumoniae. Clarithromycin has an in-vitro activity that is similar or greater than that of erythromycin against erythromycin-susceptible organisms. Clarithromycin is usually bacteriostatic, but may be bactericidal depending on the organism and the drug concentration.

mechanism of action :-

Clarithromycin is first metabolized to 14-OH clarithromycin, which is active and works synergistically with its parent compound. Like other macrolides, it then penetrates bacteria cell wall and reversibly binds to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, blocking translocation of aminoacyl transfer-RNA and polypeptide synthesis. Clarithromycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump.

TARGET	ACTIONS	ORGANISM
A50S ribosomal protein L10	inhibitor	Shigella flexneri
UPotassium voltage-gated channel subfamily H member 2	Not Available	Humans
USolute carrier organic anion transporter family member 1B1	Not Available	Humans
USolute carrier organic anion transporter family member 1B3	Not Available	Humans

 used :- 

Clarithromycin is used in the treatment of bacterial infections. It is used in infections of tonsils, sinus, ear, nose, throat, skin and soft tissues and lungs (pneumonia.

side effects :- 

Abdominal pain, Diarrhea, Nausea, Vomiting, Headache, Rash, Injection site phlebitis, Insomnia (difficulty in sleeping), Abnormal taste, Dyspepsia, Taste change, Abnormal liver function tests.

Dose:- 250mg BD for 7 days;  severe cases 500mg BD up to 14days.