CYCLOSERINE (Cs)
Brand Name:- cyclorine, covering, Myser 250mg cap.
CYCLOSERINE (Cs)is a broad-spectrum antibiotic. It kills bacteria by preventing them from forming their own protective covering (cell wall) which is required for their survival in the human body.
Pharmacodynamic :-
Cycloserine, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Cycloserine works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria.
Mechanism of action:-
Cycloserine is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.
used:-
treat tuberculosis (TB). In some cases, it may also be used to treat urinary tract infections (UTIs). It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu).
side effects:-
Headache, drowsiness, dizziness, or shaking (tremor)Vertigo, Sleepiness, Drowsiness, Tremors, Aggression, Paresis, Increased reflexes, Delirium (acute confusional state), Psychosis, Personality changes, Heart failure, Hyperirritability, Clonic seizures, Coma .
Dose:-
Strat with 250mg BD, increase if tolerated to 750mg / day for patients with body weight>45kg.
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