Skip to main content

CYCLOSERINE (Cs) Uses, Side Effects, and More

 CYCLOSERINE (Cs) 

Brand Name:-  cyclorine, covering, Myser 250mg cap. 

CYCLOSERINE (Cs)is a broad-spectrum  antibiotic. It kills bacteria by preventing them from forming their own protective covering (cell wall) which is required for their survival in the human body.

Pharmacodynamic :- 

Cycloserine, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Cycloserine works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria. 

Mechanism of action:- 

Cycloserine is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.

used:- 

treat tuberculosis (TB). In some cases, it may also be used to treat urinary tract infections (UTIs). It works by stopping the growth of bacteria.This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). 

side effects:- 

Headache, drowsiness, dizziness, or shaking (tremor)Vertigo, Sleepiness, Drowsiness, Tremors, Aggression, Paresis, Increased reflexes, Delirium (acute confusional state), Psychosis, Personality changes, Heart failure, Hyperirritability, Clonic seizures, Coma . 

Dose:- 

Strat with 250mg BD, increase if tolerated to 750mg / day for patients with body weight>45kg. 
Labels:

Comments

Post a Comment

Popular posts from this blog

Know details about Dabigatran etexilate drug ?

 Dabigatran Etexilate 
Post a Comment
Read more

Chlorthalidone Uses, Side Effects, and More....

 Chlorthalidone  Brand name:- Hythalton 50,100mg , Hydrazide, Thalizide ( 12.5, 25) . Chlorthalidone is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow. Pharmacodynamic:- Not 🚫 available.  Pharmacokinetics:- Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. As with other thiazide diuretics, ch...
Post a Comment
Read more

Captopril Uses, Side Effects, and More

 Captopril Brand name:- Angiopril 25mg tab, Aceten, Captopril 12.5, 25mg tab. Captopril is an angiotensin converting enzyme (ACE) inhibitor. It works by reducing stress on the heart and relaxing blood vessel so that blood flows more smoothly and the heart can pump blood more efficiently. Pharmacodynamic:-  Captopril, an ACE inhibitor, antagonizes the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons w...
Post a Comment
Read more