BICUCLLINE
BRAND NAME:- no specific brand available.
BICUCLLINE is synthetic convulsant has picrotoxin - like action. It is a competitive GABAa receptor ( intrinsic CI- channel receptors) antagonist, while GABAb receptor ( G- protein couple receptor) is insensitive to it. It is only a research tool .
PHARMACODYNAMIC:-
Not available .
MECHANISM OF ACTION:-
Not available.
USED:-
Used for screening for AEDs as classical anticonvulsant drugs, and especially GABAA receptor-acting drugs, are effective in this model.
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