BEZAFIBRATE
BRAND NAME:- BEZALIP 200,400mg tab.
BEZAFIBRATE rate is a lipid lowering medication. It works by lowering the levels of triglycerides and "bad" cholesterol (LDL), while raising the levels of "good" cholesterol (HDL).
PHARMACODYNAMIC:-
This is second generation fibric acid derivatives is an alternative to gemfibrozil in mixed hyperlipidemias ( type III,IV and V ) . Though it has also been indicated in hypercholesterolemia ( type II) ,it is inferior to statins and resins . Bezafibrate has not shown propensity to increase LDL- CH in hypertriglyceridaemic patients and appears to have greater LDL- CH lowering action than gemfibrozil. Circulating fibrinogen and glucose levels may decrease. The 5 year ' Bezafibrate coronary Atherosclerosis Intervention Trail '( BECAIT) in young male post - MI subjects showed an atherosclerosis slowing effects and reduction in coronary events. The Bezafibrate infarction prevention (BIP) registry has also noted reduction in coronary events in subjects with TG and low HDL- CH levels .
MECHANISM OF ACTION:-
It is generally accepted that bezafibrate is likely an agonist of PPAR-alpha. However, certain other investigations have also suggested that the substance might also elicit some effects on PPAR-gamma and PPAR-delta too.
USES:-
Treatment of high triglycerides and high cholesterol.
Used as an antidiabetic drug.
SIDE EFFECTS:-
Adverse effects and contraindications are similar to other fibrates. Main side effects are g.i. upset, myalgia, rashes. Dose reduction is needed in elderly and in renal insufficiency.
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