BENDROFLUMETHIAZIDE Uses, Side Effects, and More

 BENDROFLUMETHIAZIDE

Brand name:- Bendrofulazide, Aprinox.

BENDROFLUMETHIAZIDE is a type of medicine called a diuretic. It's used to treat high blood pressure (hypertension) and the build-up of fluid in your body (oedema).

Diuretics are sometimes called "water tablets" because they make you pee more. This helps get rid of extra fluid in your body.

Bendroflumethiazide is only available on prescription. It usually comes as tablets. It can also come as a liquid you swallow, but this has to be specially ordered. 

PHARMACODYNAMIC:- 

Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

MECHANISM OF ACTION:-

bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. 

 USED:-

used to suppress lactation and to treat hypertension and edema.

 SIDE EFFECTS:- 

Common adverse effects:-

•Feeling dizzy due to orthostatic hypotension

•Dry mouth or feeling thirsty

•Nausea

•stomach ache

•fatigue

•Diarrhea or constipation

•joint pain due to gout

Rare adverse effects

•Thrombocytopenia

•Agranulocytosis

•Photosensitivity rash

•Pancreatitis

•Chronic kidney disease

DOSE:-Direction by physician.