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BUTENAFINE ; used, Side effects, dose, pharmacodynamic, mechanism of action...

 BUTENAFINE 

BRAND NAME:- BUTOP, FINTOP 1% cream;


BUTENAFINE is a benzylamine congener of terbinafine with the same mechanism of action. However, it is used only topically in dermatophytosis . Efficacy in tinea cruris/ corporis/ pedis is similar to that of topical terbinafine.

PHARMACODYNAMIC:-

Butenafine is a synthetic antifungal agent that is structurally and pharmacologically related to allylamine antifungals. The exact mechanism of action has not been established, but it is suggested that butenafine's antifungal activity is exerted through the alteration of cellular membranes, which results in increased membrane permeability, and growth inhibition. Butenafine is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is also active against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well. 

MECHANISM OF ACTION:-

Although the mechanism of action has not been fully established, it has been suggested that butenafine, like allylamines, interferes with sterol biosynthesis (especially ergosterol) by inhibiting squalene monooxygenase, an enzyme responsible for converting squalene to 2,3-oxydo squalene. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Blockage of squalene monooxygenase also leads to a subsequent accumulation of squalene. When a high concentration of squalene is reached, it is thought to have an effect of directly kill fungal cells. 


USED:-

Used in the treatment of fungal skin infections.

SIDE EFFECTS:-

Burning sensation, Stinging sensation, Itching.

DOSE:- Apply locally once or twice daily. As directed by your doctor.

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