BIOTIN
BRAND NAME:- BIOTEN, BIOTIN
Biotin (or vitamin B7) is one of the B vitamins.It is involved in a wide range of metabolic processes, both in humans and in other organisms, primarily related to the utilization of fats, carbohydrates, and amino acids.
PHARMACODYNAMIC:-
BIOTIN is a sulfur containing organic acid found in egg yolk, liver,nuts and many other articles of food. Some of the biotin synthesis by intestinal bacteria is also absorbed.
It is well absorbed from intestine and excreted mainly unchanged in urine. Not much is stored in the body. Avidin, a heat labile protein in egg white, binds and prevent the absorption of biotin. Some other biotin antagonist are also known.
Biotin is a coenzyme for several carboxylases involved in carbohydrates and fat metabolism. Deficiency symptoms include seborrheic dermatitis, alopecia, anorexia, glossitis and muscular pain . Spontaneous deficiency of biotin has been noted only in subject consuming only raw egg white and in patients on total parenteral nutrition. Except for these unusual instance and rare genetic abnormalities of biotin dependent enzymes, there are no clearly defined therapeutic uses of biotin. It is present in some multivitamin preaprations.
MECHANISM OF ACTION:-
Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids.
USED:-
•Prevention of Biotin deficiency.
•Used in treatment of hair fall.
•Diabetic nerve pain. There is some evidence that biotin can •reduce nerve pain in people with diabetes.
•Brittle fingernails and toenails. Biotin might increase the •thickness of fingernails and toenails in people with brittle nails.
•Other conditions.
SIDE EFFECTS:-
Biotin is LIKELY SAFE for most people when taken appropriately and by mouth. Biotin is well tolerated when used at recommended dosages. It is POSSIBLY SAFE when injected into the muscles and used appropriately.
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