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BUDESONIDE

 BUDESONIDE


BRAND NAME:- PULMICORT 100,200,400 ug/ metered dose inhaler, BUDECORT 100ug/ metered dose inhalation.

FORACORT : Formoterol 6 ug + BUDESONIDE 100 ug/200ug ROTACAPS. RHINOCORT 50ug per metered dose nasal spray;

BUDENASE AQ 100ug metered dose aqueous nasal spray; 


BUDESONIDE is a nonhalogenated glucocorticoid with high Topical: systemic activity ration (greater first pass metabolism than beclomethasone). Small fraction that is absorbed is rapidly metabolized; less systemic effects,may be preferred in more severe dose.



PHARMACODYNAMIC:- 

Budesonide is a glucocorticoid used to treat respiratory and digestive conditions by reducing inflammation. It has a wide therapeutic index, as dosing varies highly from patient to patient. Patients should be counselled regarding the risk of hypercorticism and adrenal axis suppression.Budesonide appears to be retained within cells, allowing for a once-daily treatment regimen in certain patient groups.


MECHANISM OF ACTION:-

Budesonide is a potent topical anti-inflammatory agent. It binds and activates glucocorticoid receptors (GR) in the effector cell (e.g., bronchial) cytoplasm that allows the translocation of this budesonide-GR complex in the bronchi nucleus, which binds to both HDCA2 and CBP (HAT) .


USED:- 

used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis. 



DOSE :- 200-400 ug BD-QID by inhalation in asthma ; 200—400ug/day intranasal spray for allergic rhinitis.



SIDE EFFECTS:-

Nasal irritation, sneezing, crusting, itching of throat and dryness may occur, especially in the beginning, contraindicated in presence of infection or nasal ulcers.

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