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BIVALIRUDIN Uses, Side Effects, and More

 BIVALIRUDIN



BRAND NAME:- Angiomax ,Angiox


BIVALIRUDIN is a direct thrombin inhibitor . It is a smaller peptide prepared synthetically which has action, However,its action is slowly reversible due to cleavage of its peptide bonds by thrombin itself. Used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention. 


PHARMACODYNAMIC:-


Coagulation times return to baseline approximately 1 hour following cessation of bivalirudin administration. Bivalirudin mediates an inhibitory action on thrombin by directly and specifically binding to both the catalytic site and anion-binding exosite of circulating and clot-bound thrombin. The action of bivalirudin is reversible because thrombin will slowly cleave the thrombin-bivalirudin bond which recovers the active site of thrombin.

MECHANISM OF ACTION:-


Bivalirudin directly inhibits thrombin by specifically binding both to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Thrombin is a serine proteinase that plays a central role in the thrombotic process. It cleaves fibrinogen into fibrin monomers, activates Factor V, VIII, and XIII, allowing fibrin to develop a covalently cross-linked framework that stabilizes the thrombus. Thrombin also promotes further thrombin generation, and activates platelets, stimulating aggregation and granule release. The binding of bivalirudin to thrombin is reversible as thrombin slowly cleaves the bivalirudin-Arg3-Pro4 bond, resulting in recovery of thrombin active site functions. 

USES:-


used to treat heparin-induced thrombocytopenia and to prevent thrombosis during percutaneous coronary intervention.

SIDE EFFECTS:-


Cause serious side effects:-
•hives,
•difficulty breathing,
•swelling of your face, lips, tongue, or throat,
•Lightheadedness,
•easy bruising,
•unusual bleeding (nosebleeds, bleeding gums, heavy menstrual bleeding),
•bloody or tarry stools,
•coughing up blood,
•vomit that looks like coffee grounds,
•sudden numbness or weakness,
•problems with vision or speech,



DOSE:- 

Bivalirudin is intended for IV use only and is supplied as a sterile, lyophilized product in single-use, glass vials. After reconstitution, each vial delivers 250 mg of bivalirudin.
DIRECTION BY PHYSICIAN 
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