BISACODYL

 BISACODYL

BRAND NAME:- DULCOLAX 5mg,10mg tab & suppository,CONLAX 5mg ,10mg suppository,BIDLAX-5  5mg tab.

BISACODYL is a laxative. It works by increasing the movement of the intestines, thereby facilitating the passage of stool. It also helps clean out the intestines prior to medical procedures or examinations.

PHARMACODYNAMIC:-

They are partly absorbed and reexcreted  in bile. The enterohepatic circulation is greater in case of phenolphthalein which can produce protracted action. Bisacodyl is activated in the intestine by deacetylation . The primary site of action of diphenylmethanes is in the colon where they irritate the mucosa , produce mild inflammation and increase secertion. One or two semiformed motions occurs after 6-8 hours.

MECHANISM OF ACTION:-

Bisacodyl works by stimulating enteric neurons to cause peristalsis, i.e., colonic contractions. It is also a contact laxative; it increases fluid and salt secretion. The action of bisacodyl on the small intestine is negligible; stimulant laxatives mainly promote evacuation of the colon.

USED:- 

 used in the treatment of constipation.

SIDE EFFECTS:-

Common side effects of Bisacodyl are:-

Nausea, Abdominal cramp, Abdominal pain, Diarrhea.

DOSE:- 5-10mg at bed time .