BISACODYL
BRAND NAME:- DULCOLAX 5mg,10mg tab & suppository,CONLAX 5mg ,10mg suppository,BIDLAX-5 5mg tab.
BISACODYL is a laxative. It works by increasing the movement of the intestines, thereby facilitating the passage of stool. It also helps clean out the intestines prior to medical procedures or examinations.
PHARMACODYNAMIC:-
They are partly absorbed and reexcreted in bile. The enterohepatic circulation is greater in case of phenolphthalein which can produce protracted action. Bisacodyl is activated in the intestine by deacetylation . The primary site of action of diphenylmethanes is in the colon where they irritate the mucosa , produce mild inflammation and increase secertion. One or two semiformed motions occurs after 6-8 hours.
MECHANISM OF ACTION:-
Bisacodyl works by stimulating enteric neurons to cause peristalsis, i.e., colonic contractions. It is also a contact laxative; it increases fluid and salt secretion. The action of bisacodyl on the small intestine is negligible; stimulant laxatives mainly promote evacuation of the colon.
USED:-
used in the treatment of constipation.
SIDE EFFECTS:-
Common side effects of Bisacodyl are:-
Nausea, Abdominal cramp, Abdominal pain, Diarrhea.
DOSE:- 5-10mg at bed time .
Comments
Post a Comment