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BENZYL BENZOATE ; used, side effects, Dose, Pharmacodynamic & mechanism of....

 BENZYL BENZOATE 

BRAND NAME:- BENZYLBENZOATE APPLICATION 25%lotion; DERMIN 25% lotion; SCABINDON 25% oint with DDT 1% and benzocaine 2% 

BENZYL BENZOATE  is an antiparasitic medicines. It works by killing the tiny insects (mites) and their eggs, which cause scabies. It is an oily liquid with faint aromatic smell; has been popular for treatment of scabies. The emulsion is applied all over except face and neck after a cleansing bath.

PHARMACODYNAMIC:-

Benzyl benzoate is one of the older oily liquid preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties 

MECHANISM OF ACTION:-

Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes. The emulsion is applied all over except face and neck after a cleansing bath. A second coat is applied next day which is washed after 24hours . The treatment is convenient and does not interfere with routine activities. It has achieved 76-100% cure in scabies. 

USED:- 

Used in the treatment of scabies and lice.

SIDE EFFECTS:- 

Eye disorder, Hypersensitivity, Skin and subcutaneous tissue disorders


DOSE :- APPLYING WELL ALL OVER EXCEPT FACE AND NECK DAILY AFTER CLEANSING BATH. As directed by your doctor.

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