BENZOYL PEROXIDE

BRAND NAME:- PERSOL, PERNOX, BENZAC-AC 2.5% and 5%gel , PERSOL FORTE 10% cream with sulfur ppt.5%.

BENZOYL PEROXIDE is one of the most effective and widely used in acne: gradually liberates oxygen (in the presence of water) which kills bacteria, especially anaerobic/ microaerophilic ones: used almost exclusively for acne because of its High efficacy against P.acnes and additional keratolytic and comedolytic properties. P.acenes or other bacteria do not develop resistance to benzoyl peroxide. It induces mild desquamation the comedone caps are shed and production of irritant fatty acids in the sebum is reduced. Benzoyl peroxide is a mild irritant of the skin- burning and stinging sensation is often felt initially, localized erythema may occur . Most patients gradually developed tolerance to these actions; if not ,use should be discontinued. Avoid contact with eyes,lips , mucous membranes and denuded skin . It can bleach hair and coloured fabric.

PHARMACODYNAMIC:-

Benzoyl peroxide is a topical treatment for acne that generates free radicals to break down comedones and increase the rate of epithelial cell turnover. It has a short duration of action as its active free radical metabolites quickly react to form inactive metabolites.1 The therapeutic index is wide, as overdoses are rare, however patients may still experience skin peeling. Patients should be counselled regarding increased risks of skin irritation, dryness, and sunburn.

MECHANISM OF ACTION:-

The mechanism of action of hydrogen peroxide is not fully understood and is associated with its oxidation activity. The oxidation of the various molecules that constitute microorganisms will lead to significant disruptions in structure/function and the loss of viability or infectivity .

USED:-

treatment of acnes & many skin related problems.

SIDE EFFECTS:-

Skin reactions such as peeling, itching, irritation, and reddened skin may occur.

DOSE :- MAINLY LOCALY APPLYING

DIRECT BY PHYSICIAN.

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