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BECLOMETHASONE DIPROPIONATE Uses, Side Effects, and More

 BECLOMETHASONE DIPROPIONATE 



BRAND NAME:-  BECLATE INHALER 50ug,100ug ,200ug , BECORIDE 50,100,250ug ,BECLATE ROTACAPS,AEROCORT INHALOR, AEROCORT ROTACAPS.



  BECLOMETHASONE, also known as beclomethasone dipropionate, is an inhaled corticosteroid used as maintenance treatment in the prophylaxis of asthma attacks.

PHARMACOLOGY:-

Beclomethasone is mainly a glucocorticoid.Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor[15] that is present in almost every vertebrate animal cell. The activated glucocorticoid receptor-glucocorticoid complex up-regulates the expression of anti-inflammatory proteins in the nucleus (a process known as transactivation) and represses the expression of proinflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus (transrepression).



MECHANISM OF ACTION:-


BECLOMETHASONE DIPROPIONATE is a diester  of beclomethasone , a synthesis corticosteroid  chemically related to Dexamethasone.Beclomethasone dipropionate works by attenuating the inflammatory responses associated with asthma, allergic rhinitis, nasal polyps, and corticosteroid-responsive dermatoses. It suppresses the actions of inflammatory cells, such as mast cells, eosinophils, basophils, lymphocytes, macrophages, and neutrophils. 



USED:-  

To caution of respiratory infection.
The inhaled form is used in the long-term management of asthma.
The cream may be used for dermatitis and psoriasis. 
The pills have been used to treat ulcerative colitis.
The nasal spray is used to treat allergic rhinitis and nasal polyps.


SIDE EFFECTS:- 

Hoarseness of voice,dysphonia,sore throat, asymptomatic or symptomatic oropharyngeal candidiasis are the most common side effects.


DOSE:- Intranasal spray (50ug in each nostril BD- TDS ) is effective in perennial rhinitis.









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