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AMIFOSTINE (ethiofos)

 AMIFOSTINE (ethiofos)


BRAND NAME:- CYTOFOS,NAPROFOS 500mg /vial inj.



AMIFOSTINE is an organic thiophosphate which on activation by alkaline phosphate acts as a cytoprotective against cancer chemotherapy and radiotherapy.It is marketed by Clinigen Group under the trade name Ethyol .


MECHANISM OF ACTION:-

The thiol metabolite is responsible for most of the cytoprotective and radioprotective properties of amifostine. It is readily taken up by cells where it binds to and detoxifies reactive metabolites of platinum and alkylating agents as well as scavenges free radicals. Other possible effects include inhibition of apoptosis, alteration of gene expression and modification of enzyme activity.



SIDE EFFECTS:-

Short term side effects of amifostine itself are nausea, vomiting, hypotension and infusion related reaction.Delayed adverse effects is hypocalcaemia . 


USED:-

IT is particularly used for Prophylaxis of cisplatin induced neuro/nephrotoxicity, and radiotherapy related xerostomia.


DOSE:- 910mg / m2 i.v. before cisplatin infusion

              200mg/i.v. before radiotherapy.


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