Skip to main content

AMBROXOL

 AMBROXOL


BRAND NAME:- AMBRIL,AMBROLITE,AMBRODIL,MUCOLITE 30mg tab,30mg/5 ml liquid,7.5mg/ml drops.



Ambroxol a metabolite of bromhexine having similar mucolytic action.The initiation of the action occurs after about 30 minutes when administered orally. The degradation of the fibers of acid mucopolysaccharide makes the sputum thinner and less viscous and therefore easier to extract by coughing. While sputum volume gradually decreases, for as long as care is continued, its viscosity remains low.



MECHANISM OF ACTION:-

Ambroxol is a mucolytic agent. Excessive Nitric oxide (NO) is associated with inflammatory and some other disturbances of airways function. NO enhances the activation of soluble guanylate cyclase and cGMP accumulation. Ambroxol has been shown to inhibit the NO-dependent activation of soluble guanylate cyclase. It is also possible that the inhibition of NO-dependent activation of soluble guanylate cyclase can suppress the excessive mucus secretion, therefore it lowers the phlegm viscosity and improves the mucociliary transport of bronchial secretions. 



USED:-

In symptomatic treatment of tracheobronchitis, an infection that induces tracheal (windpipe) and pulmonary airway inflammation. Ambroxol in this case relieves the patient from an excessive cough and thick sputum.

Treatment of respiratory diseases.



SIDE EFFECTS:- 

Nausea,Vomiting,Diarrhea,Gastrointestinal side effects,Skin rash,itching,Infections,Allergies,Upset stomach,Dizziness,Weakness,Dry mouth,Indigestion,Numbness in throat,Numbness in mouth,Taste disturbances etc.



DOSE:- 15-30mg TDS .



Comments

Popular posts from this blog

Chlorthalidone Uses, Side Effects, and More....

 Chlorthalidone  Brand name:- Hythalton 50,100mg , Hydrazide, Thalizide ( 12.5, 25) . Chlorthalidone is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow. Pharmacodynamic:- Not 🚫 available.  Pharmacokinetics:- Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. As with other thiazide diuretics, ch...

Chlordiazepoxide Uses, Side Effects, and More

 Chlordiazepoxide Brand name:- Librium 10, 25 mg tabs; Equilibrium 10mg tab. Chlordiazepoxide is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain. Pharmacodynamic:-  Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dos...

Know details about Dabigatran etexilate drug ?

 Dabigatran Etexilate