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AMBROXOL

 AMBROXOL


BRAND NAME:- AMBRIL,AMBROLITE,AMBRODIL,MUCOLITE 30mg tab,30mg/5 ml liquid,7.5mg/ml drops.



Ambroxol a metabolite of bromhexine having similar mucolytic action.The initiation of the action occurs after about 30 minutes when administered orally. The degradation of the fibers of acid mucopolysaccharide makes the sputum thinner and less viscous and therefore easier to extract by coughing. While sputum volume gradually decreases, for as long as care is continued, its viscosity remains low.



MECHANISM OF ACTION:-

Ambroxol is a mucolytic agent. Excessive Nitric oxide (NO) is associated with inflammatory and some other disturbances of airways function. NO enhances the activation of soluble guanylate cyclase and cGMP accumulation. Ambroxol has been shown to inhibit the NO-dependent activation of soluble guanylate cyclase. It is also possible that the inhibition of NO-dependent activation of soluble guanylate cyclase can suppress the excessive mucus secretion, therefore it lowers the phlegm viscosity and improves the mucociliary transport of bronchial secretions. 



USED:-

In symptomatic treatment of tracheobronchitis, an infection that induces tracheal (windpipe) and pulmonary airway inflammation. Ambroxol in this case relieves the patient from an excessive cough and thick sputum.

Treatment of respiratory diseases.



SIDE EFFECTS:- 

Nausea,Vomiting,Diarrhea,Gastrointestinal side effects,Skin rash,itching,Infections,Allergies,Upset stomach,Dizziness,Weakness,Dry mouth,Indigestion,Numbness in throat,Numbness in mouth,Taste disturbances etc.



DOSE:- 15-30mg TDS .



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