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ALLYLESTRENOL

 ALLYLESTRENOL


BRAND NAME:- GESTANIN,FETUGARD,MAINTANE 5mg tab. ,PROFAR 25mg tab.


ALLYLESTRENOL is a progestin (female hormone). It helps in maintaining pregnancy by promoting the attachment of the embryo to lining of the womb and improving blood flow to the placenta. It also relaxes the uterus muscles thereby preventing premature labour.


INDICATIONS:-

Allylestrenol was designed to be used for miscarriage prevention, prevention of premature labour and has been investigated for possible use in men for treatment for benign prostatic hyperplasia. 


PHARMACODYNAMIC:-

Allylestrenol is a progestogen structurally related to progesterone that has been given in threatened and recurrent miscarriage, and to prevent premature labour. However, with the exception of proven progesterone deficiency, such use is no longer recommended. In threatened miscarriage in progesterone-deficient women a suggested dose is 5 mg three times daily by mouth for 5 to 7 days.


MECHANISM OF ACTION:-

Allylestrenol is similar in structure and function to progesterone. Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity. 


USED:- As a contraceptive, Hormone replacement therapy, Dysfunctional uterine bleeding, endometriosis,Premenstrual syndrome/ tension, Threatened/ habitual abortion, Endometrial carcinoma.


ADVERSE EFFECTS:-

are few and have not been well-defined, but are assumed to be similar to those of related medications.Allylestrenol is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has no other important hormonal activity. The medication is a prodrug of 17α-allyl-19-nortestosterone (3-ketoallylestrenol) in the body.



DOSE:-10-40mg/day

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