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ADRIAMYCIN (DOXORUBICIN)

 ADRIAMYCIN (DOXORUBICIN)


BRAND NAME:- DAUNOCIN,DAUNOMYCIN 20mg/vial inj. , ADRIAMYCIN, DOXORUBICIN,ONCODRIA 10 mg ,50mg per vial inj.




ADRIAMYCIN are also known as doxorubicin , doxorubicin are  anthracycline antibiotics having antitumour activity, isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.


ACTIONS:-

These are anthracycline antibiotics having antitumour activity. However, utility of daunorubicin is limited to acute myeloid as well as Lymphoblastic leukaemia (in which it is highly active), while doxorubicin,in addition,is effective in many solid tumors,such as breast, thyroid,ovary, bladder and lung cancer,scrcomas and neuroblastoma.

 They intercalate between DNA strands and block DNA as well as RNA synthesis. They are also capable of causing breaks in DNA strands by activating topoisomerase -2 and generation quinone types free radicals. As such they have mutagenic and carcinogenic potential. Maximum action is exerted at S phase ,but toxicity is usually exhibited in G2 phase .



ADVERSE EFFECTS:-

These antibiotics produce cardiotoxicity as a unique adverse effects. Causing ECG change, arrhythmias and hypotension,all of which are reversible; or be delayed — congestive heart failure. CHF is due to cardiomyopathy and may be fatal . Marrow depression, alopecia, stomatitis, vomiting and local tissues damage , urine may be coloured red. 


USED:-Doxorubicin is a medication used to treat various cancers and Kaposi's Sarcoma . 


DOSE:- 60-75mg / m²  BSA slow i.v. injection every 3 weeks .

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