Skip to main content

ACECLOFENAC

 ACECLOFENAC


BRAND NAME:- ACECLO,DOLOKIND 100mg tab ,200mg SR tab.


Aceclofenac is a non-steroidal anti-inflammatory drugs (NSAID).

ACECLOFENAC is  a moderately COX-2 selective congener of diclofenac having similar properties. It is an analgesic antipyretic and anti-inflammatory drug, enhancement of glycosaminoglycan synthesis may confer chondroprotective property to ACECLOFENAC.

 It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). 

MECHANISM & PHARMACOLOGICAL ACTION:-

 IT inhibits PG synthesis and is some what COX-2 selective . The antiplatelet action is not appreciable due to sparing of COX-1 . It also does not block the cardioprotective effect of low dose aspirin. Neutrophil chemotaxis and superoxide production at the inflammatory site are reduced.

It well absorbed orally,99% protein bound , metabolized and excreted both in urine and bile. The plasma t½ is ~ 2 hours . However it had good tissue penetrability and concentration in synovial fluid is maintained for 3 times longer period than in plasma,exerting extended therapeutic action in joints.



USE:- as a analgesic antipyretic, anti-inflammatory action .

Aceclofenac is used for pain relief. It relieves pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. 


SIDE EFFECTS:- Vomiting, Stomach pain/epigastric pain, Nausea, Indigestion, Diarrhea, Heartburn, Loss of appetite .


DOSE:- 100mg BD

Labels:

Comments

Post a Comment

Popular posts from this blog

Cefpodoxime proxetil Uses, Side Effects, and More

 Cefpodoxime proxetil Brand name:- cefoprox ,cepodem,DOXCEF 100,200mg cap.  Cefpodoxime Proxetil is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive. Pharmacodynamic:-  Cefpodoxime is shown to be effective against most Gram positive and Gram negative bacteria, except Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Mechanism of action:-  Cefpodoxime is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Cefpodoxime is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Cefpodoxime is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. The active metabolite of cefpodoxime binds preferentially to penicilli
Post a Comment
Read more

Cephalexin ( ZYD ) ( Cefalexin ) Uses, Side Effects, and More

 Cephalexin (ZYD) (Cefalexin) Brand name:-  Cephacillin 250,500mg cap; Sporidex, Alcephin,Cephaxin cap. Cephalexin (also called Cefalexin)  is the most common used orally effective first generation cephalosporin , similar in spectrum to cefazolin , but less active against penicillinase producing staphylococci and H. Influenza. Plasma protein binding is low; it attains High concentration in bile and is excreted unchanged in urine; t½ - 60min. Pharmacodynamic:-  Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic. It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that result as complications of minor wounds or lacerations.Label It is effective against most gram-positive bacteria through its inihibition of the cross linking reaction between N-acetyl muramicacid and N-acetylglucosamine in the cell wall, leading to cell lysis. Pharmacokinetics:- Cephalexin is rapidly and almost completely absorbed from t
Post a Comment
Read more

BASILIXIMAB Uses, Side Effects, and More

 BASILIXIMAB BRAND NAME:- Simulect   BASILIXIMAB is another anti CD - 25 antibody with higher affinity for the IL-2 receptor, but shorter plasma t½ (1 week) . is a monoclonal antibody used to prevent rejection in kidney transplants. It is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used in combination with other medicines used to prevent organ rejection. PHARMACODYNAMIC:- Basiliximab functions as an IL-2 receptor antagonist. Specifically it inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection.  MECHANISM OF ACTION:-  Basiliximab competes with IL-2 to bind to the alpha chain subunit of the IL2 receptor on the surface of the activated T lymphocytes and thus prevents the receptor from signaling. This prevents T cells from replicating and also from activating B cells, which are responsible for the production of antibodies, which would bind to the trans
1 comment
Read more