Skip to main content

Dalteparin used, Side effects, Mechanism of action & more......

 Dalteparin  


Brand name:- Fragmin 2500, 5000 IU prefilled syringes.

 Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis.

Pharmacodynamic:-

Dalteparin has an antithrombin binding site that is essential for high affinity binding to the plasma protein antithrombin (ATIII). Anti-Xa activity of plasma is used as both as an estimate of clotting activity, and as a basis to determine dosage. Its use should be avoided in patients with a creatinine clearance less than 20ml/min. In these patients, unfractionated heparin should only be used. As for monitoring, active partial thromboplastin time (aPTT) will only increase at high doses of low molecular weight heparins (LMWH). Therefore, monitoring aPTT is not recommended. However, anti-Xa activity can be measured to monitor the efficacy of the LMWH.

 Mechanism of action:- 

Dalteparin Injection is an anticoagulant medication belonging to the class of low molecular weight heparins. Dalteparin binds to the antithrombin to form a complex. Antithrombin is a protein that blocks the formation of abnormal blood clots. Dalteparin inhibits the clotting factors factor Xa and thrombin, eventually preventing clot formation.

Used:- 

Used to prevent acute coronary syndrome, deep vein thrombosis and pulmonary embolism. It prevents the formation of blood clots in the legs, lungs, brain or heart.

Side effects:-

Bruise, Increased liver enzymes, Injection site hematoma, Hemorrhagic complications, Injection site bruising, Nosebleeds.

 Dose :-  2500 IU OD for prophylaxis; 100U/kg 12 hourly or 200U/kg 24 hourly for treatment of deep vein thrombosis.


Labels:

Comments

Post a Comment

Popular posts from this blog

BASILIXIMAB Uses, Side Effects, and More

 BASILIXIMAB BRAND NAME:- Simulect   BASILIXIMAB is another anti CD - 25 antibody with higher affinity for the IL-2 receptor, but shorter plasma t½ (1 week) . is a monoclonal antibody used to prevent rejection in kidney transplants. It is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used in combination with other medicines used to prevent organ rejection. PHARMACODYNAMIC:- Basiliximab functions as an IL-2 receptor antagonist. Specifically it inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection.  MECHANISM OF ACTION:-  Basiliximab competes with IL-2 to bind to the alpha chain subunit of the IL2 receptor on the surface of the activated T lymphocytes and thus prevents the receptor from signaling. This prevents T cells from replicating and also from activating B cells, which are responsible for the production of antibodies, which would bind to the trans
1 comment
Read more

Cefpodoxime proxetil Uses, Side Effects, and More

 Cefpodoxime proxetil Brand name:- cefoprox ,cepodem,DOXCEF 100,200mg cap.  Cefpodoxime Proxetil is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive. Pharmacodynamic:-  Cefpodoxime is shown to be effective against most Gram positive and Gram negative bacteria, except Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Mechanism of action:-  Cefpodoxime is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Cefpodoxime is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Cefpodoxime is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. The active metabolite of cefpodoxime binds preferentially to penicilli
Post a Comment
Read more

Know details about AMIKACIN DRUG ?

 AMIKACIN BRAND NAME:- AMICIN , MIKACIN, MIKAJECT 100mg ,250mg,500mg in 2ml inj. AMIKACIN it is a semisynthetic derivative of KANAMYCIN to which it resembles in pharmacokinetics,dose and toxicity. The outstanding feature of AMIKACIN is its resistance to bacterial aminoglycoside inactivating enzymes. Thus, it has to the widest spectrum of activity, including many organisms resistant to other aminoglycoside. However, relatively higher doses are needed for pseudomonas, Proteus and Staph. Infections.  The range of condition in which AMIKACIN can be used is the same as for gentamicin. It is recommended as a reserve drug for empirical treatment of hospital acquired gram-negative bacillary infections where gentamicin/tobramycin resistance is High. It is effective in  tuberculosis,but used only for multidrug resistant infection.More hearing loss than vestibular disturbances occurs in toxicity.  Pharmacodynamic:-  Amikacin is an aminoglycoside antibiotic. Aminoglycosides bind to the bacteria, c
Post a Comment
Read more