Clopamide used, side effects, dose & more....

 Clopamide

Brand name:- Brinaldix 20.

Clopamide is an oral diuretic agent with antihypertensive activity. Like thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure. This medication is a piperidine diuretic, prescribed for fluid retention. It reduces the action of adrenaline and noradrenaline

Pharmacodynamic:-

🚫 Not available.

 Mechanism of action:- 

Clopamide is categorised as a thiazide -like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equi osmolar excretion of water along with sodium chloride.

Used:- 

Used in combination to treat High blood pressure (hypertension).

Side effects:- 

Nausea, vomiting, diarrhea, loss of appetite, blurred vision, dizziness and decrease in sexual interest.

Miscellaneous - Muscle pain, muscle weakness, dry mouth, increased thirst, irregular heart beat and jaundice.

Dose:- 10- 60mg daily, as directed by your doctor.