Clobetasol Butyrate
Brand name:- Eumosone cream. Clobetasol cream, clobeta.
Clobetasone is a corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions. Topical clobetasone butyrate has shown minimal suppression of the Hypothalamic-pituitary-adrenal axis.
Pharmacodynamic:-
Topical corticosteroid like clobetasone are synthetic derivatives of cortisone which produce anti-inflammatory, antiproliferative, immunosuppressive and vasoconstrictor effects when applied to the skin.
Mechanism of action:-
Topically applied clobetasol are thought to bind with cytoplasmic receptors in the dermal and intradermal cells and to induce inhibitory proteins, thus leading to decreased activity of prostaglandins, kinins, histamine, liposomal enzymes and other endogenous mediators of inflammation. Topical corticosteroids inhibit the migration of macrophages and leukocytes into areas of inflamed skin by reversing vascular dilation and permeability, resulting in decreased erythema, edema and pruritus.
Used:-
Used on the skin to treat swelling, itching and irritation. It can help with skin problems such as: eczema,
side effects:-
Skin atrophy, Telangiectasia, Skin irritation, Dry skin.
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