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Cinacalcet used, Side, Doses, mechanism of action & more

 Cinacalcet 

Brand name:- Pth. , Mimcipar , cercal, setz, cinlet.

Cinacalcet is a medication used to treat tertiary hyperparathyroidism, parathyroid carcinoma, and primary hyperparathyroidism.Cinacalcet acts as a calcimimetic (i.e., it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues.

Pharmacodynamic:- 

Cinacalcet is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues). Secondary hyperparathyroidism (HPT) in patients with chronic kidney disease (CKD) is a progressive disease, associated with increases in parathyroid hormone (PTH) levels and derangements in calcium and phosphorus metabolism. Increased PTH stimulates osteoclastic activity resulting in cortical bone resorption and marrow fibrosis. The goals of treatment of secondary hyperparathyroidism are to lower levels of PTH, calcium, and phosphorus in the blood, in order to prevent progressive bone disease and the systemic consequences of disordered mineral metabolism. In CKD patients on dialysis with uncontrolled secondary HPT, reductions in PTH are associated with a favorable impact on bone-specific alkaline phosphatase ( BALP), bone turnover and bone fibrosis. Cinacalcet reduces calcium levels by increasing the sensitivity of the calcium sensing receptor to extracellular calcium.

Mechanism of action:- 

Cinacalcet directly lowers parathyroid hormone levels by increasing the sensitivity of the calcium sensing receptors to activation by extracellular calcium, resulting in the inhibition of PTH secretion. The reduction in PTH is associated with a concomitant decrease in serum calcium levels.

Used:- 

Used in the treatment of high calcium levels in the blood and hyperparathyroidism.

Side effects:- 

Nausea, Vomiting, Weakness, Headache, Dizziness, Rash, Back pain, Muscle pain, Upper respiratory tract infection, Paresthesia (tingling or pricking sensation), Diarrhea, Decreased appetite, Constipation, Hypersensitivity reaction, Decreased calcium level in blood, Hypotension (low blood pressure), Breathlessness, Cough, Dyspepsia, Abdominal pain, Muscle spasm.

Doses:- As directed by your doctor.

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