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Cefadroxil Uses, Side Effects, and More

 Cefadroxil

Brand name:- Droxyl 0.5 ,cefadrox , Keffloxin 0.5 cap .0.25 Distab ,125mg/5ml susp.

Cefadroxil is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

Pharmacodynamic:-

Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.

Pharmacokinetics:-

Cefadroxil is almost completely absorbed from the gastrointestinal tract. After doses of 500 mg and 1 g by mouth, peak plasma concentrations of about 16 and 30 micrograms/ml, respectively, are obtained after 1.5 to 2.0 hours. Although peak concentrations are similar to those of cefalexin, plasma concentrations are more sustained. Dosage with food does not appear to affect the absorption of cefadroxil. About 20% of cefadroxil is reported to be bound to plasma proteins. Its plasma half-life is about 1.5 hours and is prolonged in patients with renal impairment.

Cefadroxil is widely distributed to body tissues and fluids. It crosses the placenta and appears in breast milk. More than 90% of a dose of cefadroxil may be excreted unchanged in the urine within 24 hours by glomerular filtration and tubular secretion; peak urinary concentrations of 1.8 mg/ml have been reported after a dose of 500 mg. Cefadroxil is removed by haemodialysis.

 Mechanism of action:- 

Cefadroxil is a semisynthesis first - generation cephalosporin antibiotic more effective against gram negative bacteria intended for oral adminstration for skin infection and respiratory tract infection. Cephalosporin are bactericidal because of their inhibition of cell wall synthesis.

Used:- 

Used to treat a wide variety of bacterial infections. It belongs to a class of drugs known as cephalosporin antibiotics.

Side effects:-

Stomach upset, nausea, vomiting, or diarrhea may occur.

 Dose:-  0.5 - 1g BD.

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