Cefaclor
Brand name:- Keflor ,vercef , Distaclor 250mg cap. 50mg/ml ped. Drop.
Cefaclor is a second-generation cephalosporin antibiotic used to treat certain bacterial infections such as pneumonia and infections of the ear, lung, skin, throat, and urinary tract. It is also available from other manufacturers as a generic.
Pharmacodynamic:-
Cefaclor is a second generation cephalosporin antibiotic with a spectrum resembling first-generation cephalosporins. In vitro tests demonstrate that the bactericidal action of the cephalosporins results from inhibition of cell-wall synthesis. As indicated by in vitro and in vivo clinical studies, cefaclor was shown to be effective against most strains of Gram positive aerobes - Staphylococci (including coagulase-positive, coagulase-negative, and penicillinase-producing strains), Streptococcus pneumoniae, Streptococcus pyogenes (group A ß-hemolytic streptococci), as well as Gram-negative aerobes - Escherichia coli, Haemophilus influenzae (including ß-lactamase-producing ampicillin-resistant strains), Klebsiella sp, and Proteus mirabilis.
Mechanism of action:-
Cefaclor, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that cefaclor interferes with an autolysin inhibitor.
used:-
Used to treat a wide variety of bacterial infections (such as middle ear, skin, urine and respiratory tract infections). It works by stopping the growth of bacteria.This antibiotic only treats bacterial infections. It will not work for viral infections (such as common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.
Side effects:-
Stomach upset, headache, nausea, vomiting, or diarrhea may occur.
Doses:- 0.25 -1.0 g 8 hourly
As directed by your doctor.
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