Cefazolin Uses, Side Effects, and More

 Cefazolin

Brand name:- Reflin , Alcizon, Orizolin 0.25g , 0.5g ,1g per vial inj.

Cefazolin is a broad-spectrum cephalosporin antibiotic mainly used for the treatment of skin bacterial infections and other moderate to severe bacterial infections in the lung, bone, joint, stomach, blood, heart valve, and urinary tract.

Pharmacodynamic:- 

Cefazolin (also known as cefazoline or cephazolin) is a semi-synthetic first generation cephalosporin for parenteral administration. Cefazolin has broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.

Mechanism of action:- 

Cefazolin inhibits cell wall biosynthesis by binding penicillin-binding proteins which stops peptidoglycan synthesis. Penicillin-binding proteins are bacterial proteins that help to catalyze the last stages of peptidoglycan synthesis, which is needed to maintain the cell wall. They remove the D-alanine from the precursor of the peptidoglycan. The lack of synthesis causes the bacteria to lyse because they also continually break down their cell walls. Cefazolin is bactericidal, meaning it kills the bacteria rather than inhibiting their growth.

Used:- 

used to treat a wide variety of bacterial infections. It may also be used before and during certain surgeries to help prevent infection. 

Side effects:- 

Swelling, redness, pain, or soreness at the injection site may occur. This medication may also rarely cause loss of appetite, nausea, vomiting, diarrhea, or headache. 

Dose:- 0.5g  8hourly (mild cases), 1g 6hourly (severe cases), children 25-50mg/kg/day i.m. or i.v.; Surgical prophylaxis 1.0 g  1/2 hour before surgery.