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Carbimazole Uses, Side Effects, and More

 Carbimazole

Brand name:-  Carbazole, Thyrocab , ANTI- thyrox ,Thyrozol .

Carbimazole is an anti-thyroid medication. It works by reducing the amount of thyroid hormones produced by the thyroid gland.

Pharmacodynamic:-

Carbimazole is a carbethoxy derivative of methimazole. Its antithyroid action is due to its conversion to methimazole after absorption. It is used to treat hyperthyroidism and thyrotoxicosis.

 Mechanism of action:- 


Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 .


Used:- 

used in the treatment of hyperthyroidism.

side effects:-

Skin rash, Headache, Nausea, Joint pain, Itching, Gastrointestinal disturbance

 Dose:-  5-15mg TDS initially, maintenance dose 2.5-10mg daily in 1-2divided doses.

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