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CLOFAZIMINE (Clo) Uses, Side Effects, and More

 CLOFAZIMINE (Clos) 

BRAND NAME:- CLOFOZINE, HANSEPRAN 50mg , 100mg cap. 

ClOFAZIMINE is used together with other medicines to treat a form of leprosy (also known as Hansen's disease), called lepromatous leprosy, including dapsone-resistant lepromatous leprosy, and lepromatous leprosy complicated by erythema nodosum leprosum.

PHARMACODYANIMCS :-

Clofazimine exerts a slow bactericidal effect on Mycobacterium leprae (Hansen's bacillus) due primarily to its action on the bacterial outer membrane, though there is some evidence that activity on the bacterial respiratory chain and ion transporters may play a role. It also exerts anti-inflammatory properties due to the suppression of T-lymphocyte activity. Clofazimine has a relatively long duration of action owing to its long residence time in the body, but is still administered daily.
Approximately 75-100% of patients receiving clofazimine will experience an orange-pink to brownish-black discoloration of the skin, conjunctivae, and bodily fluids. Skin discoloration may take several months or years to reverse following the cessation of therapy. Clofazimine has also been implicated in abdominal obstruction, in some cases fatal, due to the deposition of drug and formation of crystals in the intestinal mucosa - complaints of abdominal pain and nausea/vomiting should be investigated promptly, and the doses of clofazimine should be lowered or discontinued if it is found to be the culprit.
Its use should be avoided in patients with hepatic dysfunction. 

 MECHANISM OF ACTION:- 

Clofazimine (CZM) is an antileprosy drug that was recently repurposed for treatment of multidrug-resistant tuberculosis. In Mycobacterium tuberculosis, CZM appears to act as a prodrug, which is reduced by NADH dehydrogenase (NDH-2), to release reactive oxygen species upon reoxidation by O2. 

USED:- 

Clofazimine is used in the treatment of leleprosy. 

SIDE EFFECTS:- 

Skin discoloration, Ichthyosis, Xeroderma, Gastrointestinal didisorder. 

DOSE:- AS DIRECTED BY YOUR DOCTOR. 


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