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CO TRIMOXAZOLE Uses, Side Effects, and More

 CO TRIMOXAZOLE

Brand name:- SEPTRAN, SEEMAX, BACTRIM, CIPLIN, ORIPRIM, SUPRISTOL, FORTRIM 

CO TRIMOXAZOLEDS 800mg/160mg Tablet is a combination medicine that is used to treat various types of bacterial infections such as pneumonia, bronchitis, infections of the urinary tract, ear, and abdomen. It prevents the growth of microorganisms to cure the infection.

PHARMACODYANIMCS:-

Co-trimoxazole is a combination of trimethoprim and sulfamethoxazole and is in a class of medications called sulfonamides. It works by stopping the growth of bacteria. Antibiotics will not kill viruses that can cause colds, flu, or other viral infections.

 Mechanism of action:- 

•Sulfamethoxazole -> inhibits bacterial synthesis of dihydrofolic acid
•Trimethoprim -> blocks production of tetrahydrofolic acid
-> blocks two consecutive steps in the biosythesis of nucleic acids and proteins essential to bacteria.


used:- 

Use as treatment of systemic bactrerial infection:- 
• Urinary Track infections
• Respiratory tract infection
• Bactrerial diarrhoeas and dysentery
• Pneumocystis Jiroveci
• Chancroid 
•Typhoid 


side effects:- 

•Nausea
•Vomiting
•Skin rash
•Allergic reaction

Dose:-

Trimethoprim            Sulfamethoxazole 
80mg             +         400mg tab: 2BD for                                               2days    then 1BD.
160mg           +         800mg tab: double                                               strength (DS) ; 1BD.
20mg              +        100mg pediatric tab. 
40mg               +       200mg   per 5ml susp;                                        infant 2.5ml (not to be                                       used in newborns),                                            children 1-5 yr 5ml , 6-12                                     year 10ml (all BD). 
160mg          +        800mg  per 3ml for I. M                                      injection 12hourly.
80mg            +       400mg per  5ml for I. V.                                        Injection 10-15ml BD. 

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