Skip to main content

BAL ( BRITISH ANTILEWISITE ) , DIMERCAPROL

 BAL ( BRITISH ANTILEWISITE ) , DIMERCAPROL 


BRAND NAME:- BAL INJ mg/2ml ( in arachis oil) inj.

DIMERCAPROL is a chelating agent used as an antidote to arsenic, gold, and mercury poisoning, as well as acute lead poisoning in combination with edetate calcium disodium.

PHARMACODYNAMIC:-

Due to its oily nature, dimercaprol is not absorbed orally and its administration requires a deep intra-muscular injection that is extremely painful and allergenic. It was found to mobilize and relocate lead to the brain, increasing its neurotoxic effects. Despite that fact that dimercaprol increases cadmium excretion, there is an associated increase in kidney cadmium concentration. Because of this, dimercaprol must be avoided in patients with cadmium toxicity.

 MECHANISM OF ACTION:-

The sulfhydryl groups of dimercaprol form complexes with certain heavy metals thus preventing or reversing the metallic binding of sulfhydryl-containing enzymes. The complex is excreted in the urine.


 USED:- 

used to treat arsenic, gold, or mercury poisoning. It is also used together with another medicine called edetate disodium (EDTA) to treat lead poisoning.


SIDE EFFECTS:- 

Nausea, Vomiting, Headache, Burning sensation in throat, Burning sensation in lips, Burning sensation in mouth, Feeling of constriction, Conjunctivitis, Lacrimation (flow of tears), Eye twitching, Runny nose, Salivation, Tingling of extremity, Burning sensation in the penis, Sweating, Abdominal pain, Sterile abscesses, Anxiety, Weakness.


DOSE:-  DIRECTED BY PHYSICIAN & DOCTORS.

Labels:

Comments

Post a Comment

Popular posts from this blog

Chlorthalidone Uses, Side Effects, and More....

 Chlorthalidone  Brand name:- Hythalton 50,100mg , Hydrazide, Thalizide ( 12.5, 25) . Chlorthalidone is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow. Pharmacodynamic:- Not 🚫 available.  Pharmacokinetics:- Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. As with other thiazide diuretics, ch...
Post a Comment
Read more

Chlordiazepoxide Uses, Side Effects, and More

 Chlordiazepoxide Brand name:- Librium 10, 25 mg tabs; Equilibrium 10mg tab. Chlordiazepoxide is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain. Pharmacodynamic:-  Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dos...
Post a Comment
Read more

Know details about Dabigatran etexilate drug ?

 Dabigatran Etexilate 
Post a Comment
Read more