BISHYDROXYCOUMARIN ( DICUMAROL) Uses, Side Effects, and More

 BISHYDROXYCOUMARIN ( DICUMAROL)

BRAND NAME:- DICOUMAROL 50mg tab.

BISHYDROXYCOUMARIN ( DICUMAROL ) is a naturally occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol inspired) , and is slowly and unpredictably absorbed orally. Its metabolism is dose dependent — t½ is prolonged at higher doses. Has poor g.i. tolerance; not preferred now.

PHARMACODYNAMIC:-

Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X).

 

MECHANISM OF ACTION:-

Like all 4-hydroxycoumarin drugs it is a competitive inhibitor of vitamin K epoxide reductase, an enzyme that recycles vitamin K, thus causing depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes. These compounds are not antagonists of Vitamin K directly—as they are in pharmaceutical uses—but rather promote depletion of vitamin K in bodily tissues allowing vitamin K's mechanism of action as a potent medication for dicoumarol toxicity. The mechanism of action of Vitamin K along with the toxicity of dicoumarol are measured with the prothrombin time (PT) blood test. 

USED:- 

It is also used in biochemical experiments as an inhibitor of reductases. 

used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). Dicumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). 

SIDE EFFECTS:-

•Unusual bleeding.

•A Change In Vision.

•Blurred Vision.

•Decreased Appetite.

•Gas.

•Hair Loss. 

DOSE:- DIRECTION BY PHYSICIAN.