BETHANECHOL Uses, Side Effects, and More

 BETHANECHOL

BRAND NAME:- Duvoid, Myotonachol (Glenwood), Urecholine (Merck Frosst) and Urocarb (Hamilton). 

 BETHANECHOL is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action.

Bethanechol is a muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention. 

 

PHARMACODYNAMIC:-

Bethanechol is selective for muscarinic receptors and has little to no impact on nicotinic receptors.1 The charged quaternary amine in the structure of bethanechol prevents it from crossing the blood-brain barrier which minimizes central nervous system related adverse effects. 

MECHANISM OF ACTION:-

Bethanechol is a direct muscarinic agonist and stimulates the parasympathetic nervous system by binding to postganglionic muscarinic receptors.

Though there are 5 types of muscarinic receptors (M1, M2, M3, M4, M5), binding of bethanechol to M3 is most clinically significant since M3 receptors are present in intestinal smooth muscle and the bladder.2 The cholinergic effects of bethanechol lead to increased detrusor muscle tone to promote bladder emptying and increased smooth muscle tone which restores gastrointestinal peristalsis and motility.

As a result of selectivity for muscarinic receptors, bethanechol produces minimal to no nicotinic effects. 

USED:- 

used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention. 

SIDE EFFECTS:-

•Belching.

•Blurred vision or change in near or distance vision.

•Dizziness or lightheadedness.

•Feeling faint.

•Frequent urge to urinate.

•Increased watering of mouth or sweating.

•Nausea or vomiting.

•Redness or flushing of skin or feeling of warmth. 

DOSE:-  DIRECTION BY PHYSICIAN.