BENOXINATE Uses, Side Effects, and More

BENOXINATE

BRAND NAME:- BENDZON 0.4% eyedrops.

BENOXINATE is also known as Oxybuprocaine. It is a good surface anaesthetic for the eye ; has little irritancy. A 0.4% solution rapidly produced corneal anaesthesia sufficient for tonometry without causing mydriasis or corneal damage.

PHARMACODYNAMIC:-

BENOXINATE is a local anaesthetic. It may be less irritating than tetracaine, and the onset and duration of action are similar to tetracaine.

PHARMACOKINETICS:-

Anaesthesia starts with a latency of 30 to 50 seconds and lasts for about 10 to 30 minutes, depending on perfusion. The drug is metabolised by esterases in blood plasma and liver.

MECHANISM OF ACtion:-

BENOXINATE binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.

USED:-

A local anesthetic, which is used especially in ophthalmology and otolaryngology.

SIDE EFFECTS:-

Allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue. changes in vision.

DOSE:- DIRECTION BY PHYSICIAN.

Chlorthalidone Uses, Side Effects, and More....

Chlorthalidone Brand name:- Hythalton 50,100mg , Hydrazide, Thalizide ( 12.5, 25) . Chlorthalidone is a diuretic which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow. Pharmacodynamic:- Not 🚫 available. Pharmacokinetics:- Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. As with other thiazide diuretics, ch...

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