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BUMETANIDE

 BUMETANIDE


BRAND NAME:- BUMET ,1mg tab , 0.25mg/ml inj.

BUMETANIDE is similar to furosemide in all respects & sulfamyl diuretic , but is 40 times more potent. It induces very rapid diuresis and is highly effective in Pulmonary edema. 


PHARMACODYNAMIC:-
Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys. The main difference between bumetanide and furosemide is in their bioavailability and potency. About 60% of furosemide is absorbed in the intestine, and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%). About 80% of bumetanide is absorbed, and its absorption does not change when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.[11] Bumetanide is 40 times more potent than furosemide for people with normal renal function. 


MECHANISM OF ACTION:-
Bumetanide interferes with renal cAMP and/or inhibits the sodium-potassium ATPase pump. Bumetanide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis .


USES:-
used to reduce extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, and kidney disease. 

SIDE EFFECTS:-
Common side effects include dizziness, low blood pressure, low blood potassium, muscle cramps, and kidney problems.[1] Other serious side effects may include hearing loss and low blood platelets. 

DOSE:- 1-5 mg oral OD in the morning,2-4 mg i.m/i.v (max.15mg/day in renal failure).

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