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BRAN ( Dietary fibres)used, Side dose, pharmacodynamic & mechanism of action......

 BRAN ( Dietary fibre)


BRAND NAME:- many local brands available in India 🇮🇳.


BRAN is a dietary fibre consists of unabsorbable cell wall and other constituents of vegetables food — cellulose, lignins,gums,pectins, glycoproteins and others polysaccharides.



PHARMACOLOGICAL & MECHANISM OF ACTION:-

 Bran is the residual product of flour industry which consists of ~40% dietary fibre. It absorbs water in the intestine,swells, increases water content of faeces — softens it and facilitates colonic transit. Osmotically active products may be formed in the colon by bacterial degradation of pectins, gums etc. Which act to retain water. Dietary fibre supports bacterial growth in colon which contributes to the faecal mass. Certain Dietary fibres (gums, lignins, pectins) bind bile acids and promote their excretion in faeces » degradation of cholesterol in liver is enhanced » plasma LDL- cholesterol may be somewhat lowered. Increased intake of dietary fibres is the most appropriate method for prevention of functional constipation. It is first line approach for most patients of simple constipation. Prolonged intake of bran and other bulk forming agents reduces rectosigmoid intraluminal pressure and helps to relieve symptoms of irritable bowel syndrome (IBS) including pain, constipation as well as Diarrhoea . Symptoms of chronic diverticulosis may also be relived . It also useful when straning at stools has to be avoided.



DRAWBACKS:- 

Bran is generally safe, but it is unpalatable,large quantity (20-40 g/day) needs to be ingested. It has been included in some breakfast cereals, biscuits,etc. Full effect requires daily intake for at least 3-4 days . It does not softens faeces already present in colon or rectum. As such ,bran is useful for prevention of constipation,but not for treating already constipated subjects. Flatulence may occur. It should not be used in patients with gut ulceration , adhesion, stenosis and when faecal impaction is a possibility.


USED:-

•Constipation 
•Hemorrhoids 
• stomach pain (irritable bowel syndrome or IBS), 
• effective in Diabetic
• effective in colon cancer, rectal cancer.
•Diabetes. It isn't clear if adding wheat bran to the diet can •improve blood sugar control in people with diabetes.
•Cancer.
•High blood pressure.
•High cholesterol.
•Other conditions. 



SIDE EFFECTS:-

It may cause gas (flatulence) and stomach discomfort, especially when first used. 

DOSE:- DIRECTION BY PHYSICIAN, PHARMACIST & DOCTOR.
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