BETAMETHASONE

 BETAMETHASONE 

BRAND NAME:- BETNESOL ,BETACORTRIL ,CELESTONE 0.5mg ,1mgtab,BETNELAN 0.5mg ,1mg tabs. 

BETAMETHASONE is a steroid (also called a corticosteroid). Steroids help to reduce inflammation in the skin (and other parts of your body). Skin gets inflamed when an allergic reaction or irritation causes chemicals to be released in the skin. 

PHARMACOLOGY:-

Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. 

MECHANISM OF ACTION:-

Betamethasone binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. It has anti-inflammatory activity and can suppress the immune system. Corticosteroids can also stop skin cells from growing and multiplying.

USED:- 

Used in inflammatory and allergic conditions. For shock, cerebral edema.

DOSE:- 0.5 - 5mg/day oral, 4-20mg  i. m., i.v injection or infusion,also topical .

SIDE EFFECTS:-

skin irritation ,thinning of the skin where you will apply betamethasone,cataracts or glaucoma,diabetes,liver disease,adrenal gland problems; orany type of skin infection.