BENZNIDAZOLE
Brand name:- Unkown
BENZNIDAZOLE is a trypanocidal agent used to treat Chagas disease. Benznidazole was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to benznidazole, but further studies are needed.
Pharmacodynamic:-
Benznidazole is a trypanocidal agent which kills the causative organism in Chagas disease, Trypanosoma cruzi .Benznidazole is a nitroimidazole antiparasitic with good activity against acute infection with Trypanosoma cruzi, commonly referred to as Chagas disease. Like other nitroimidazoles, benznidazole's main mechanism of action is to generate radical species which can damage the parasite's DNA or cellular machinery.
MECHANISM OF ACTION:-
Benznidazole is thought to be reduced to various electrophilic metabolites by nitroreductases present in Trypanosoma cruzi 1. These metabolites likely bind to proteins, lipids, DNA, and RNA resulting in damage to these macromolecules. Benznidazole has been found to increase trypanosomal death through interferon-γ which is likely present in increased amounts due to inflammation caused by macromolecule damage 3. DNA in parasites affected by benznidazole has been found to undergo extensive unpacking with overexpression of DNA repair proteins supporting the idea of DNA damage contributing to the mechanism of the drug .
USED:-
Used to treat Chagas disease in children ages 2 through 12 years.
SIDE EFFECTS:-
Common side effects are abdominal pain,rash,weight loss,headache,nausea,vomiting,low white blood cell count(neutropenia, eosinophilia),hives skin allergy etc.
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