AZTREONAM

 AZTREONAM

BRAND NAME:- AZENAM ,TREZAM 0.5,1.0,2.0 g/ vial inj .

AZTREONAM is a novel Beta- lactam antibiotic in which the other ring is missing (hence monobactam ) , but acts by binding to specific PBPs. It inhibits gram- negative enteric bacilli and H.influenzae .

PHARMACOLOGY:- 

it is a novel Beta-lactam antibiotic in which the other ring is missing ( hence monobactam), but acts by binding to specific PBPs . It inhibits gram-negative enteric bacilli and H. Influenzae at very low concentrations and pseudomonas at moderate concentration,but does not inhibits gram - positive cocci or faecal anaerobes. Thus ,it is a Beta - lactam antibiotic with a spectrum resembling aminoglycosides,and is resistant to gram - negative Beta - lactamases . The main indications of Aztreonam are hospital acquired infection originating from urinary, biliary, Gastrointestinal and female genital tracts . 

MECHANISM OF ACTION:-

Aztreonam is similar in action to penicillin. The bactericidal action of aztreonam results from the inhibition of bacterial cell wall synthesis due to a high affinity of aztreonam for penicillin binding protein 3 (PBP3). By binding to PBP3, aztreonam inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that aztreonam interferes with an autolysin inhibitor. 

It is eliminated unchanged in urine with a t½ of 1.8 hr. 

USED:-

used to treat the symptoms of bacterial infections of the blood, urinary tract, lungs, skin, stomach, or female reproductive organs and Cystic Fibrosis. Azactam Injection may be used alone or with other medications. 

SIDE EFFECTS:- 

Rashes and rise in serum aminotransferases are the notable adverse effects.

Azactam may cause serious side effects including:

hives,difficulty breathing,swelling of your face, lips, tongue, or throat,severe skin reaction,fever,sore throat,burning eyes,skin pain,red or purple skin rash with blistering and peeling,severe stomach pain,diarrhea that is watery or bloody .

DOSE:- 0.5 - 2 g i.m. or i.v. 6-12 hourly.