AZELAIC ACID : used, Side effects, dose, pharmacodynamic & mechanism of action....

 AZELAIC ACID 

BRAND NAME:- AZIDERM 10% ,20% cream.

It is a natural product from pityrosporum ovale that has been developed for topical treatment of acne. It has antimicrobial and anti-inflammatory properties, which make it effective in the treatment of skin conditions like acne and rosacea. The acid can prevent future outbreaks and clean bacteria from your pores that causes acne.

 PHARMACOLOGY:-

AZELAIC ACID is a natural product from pityrosporum ovale that has been developed for topical treatment of acne. Many aerobic and anaerobic microorganisms, especially P.acnes present on acne bearing skin are inhibited. Azelaic acid reduces cutaneous bacterial density,free fatty acids content of skin surface lipids and proliferation of keratinocytes. It is a weak demelanizing  agent with reversible hypopigmentary action. 

MECHANISM OF ACTION:- 

The exact mechanism of action of azelaic acid is not known.Azelaic acid is a competitive inhibitor of mitochondrial oxidoreductases and of 5 alpha-reductase, inhibiting the conversion of testosterone to 5-dehydrotestosterone. It also possesses bacteriostatic activity to both aerobic and anaerobic bacteria including Propionibacterium acnes. 

USED:-

 Azelaic acid topical cream is used to treat mildly to moderately inflamed acne. The topical foam and gel are used to treat mild to moderate rosacea. For acne, it works by killing the bacteria that cause acne and by keeping the skin pores clean. This medicine is available only with your doctor's prescription. 

SIDE EFFECTS:- 

side effects is mild and Transient local irritation .

DOSE:- TOPICAL APPLY ONLY