ATOSIBAN 
BRAND NAME:- TOsiban or others brand available in India 🇮🇳.
ATOSIBAN is a peptide analogue of oxytocin that acts as antagonist at the oxytocin receptors , used to delay imminent preterm birth in pregnant adult women displaying specific clinical observations.
PHARMACODYNAMIC:-
ATOSIBAN IS an inhibitor of oxytocin and vasopressin reduces the frequency of uterine contractions to delay pre-term birth in adult females and induces uterine quiescence .
MECHANISM OF ACTION:-
Atosiban works by blocking the action of a natural hormone called Oxytocin. It is hormone which causes the uterus (womb) to contract. Blocking the action of Oxytocin helps to delay the premature birth of the baby ,it has been found to suppress premature uterine contractions and postpone preterm delivery with fewer cardiovascular and metabolic complications than Beta2 adrenergic agonists . It binds to membrane bound oxytocin receptors on the myometrium and prevents oxytocin-stimulated increases in inositol triphosphate production 1. This ultimately prevents release of stored calcium from the sarcoplasmic reticulum and subsequent opening of voltage gated calcium channels. This shutdown of cytosolic calcium increase prevents contractions of the uterine muscle, reducing the frequency of contractions and inducing uterine quiescence .
In Europe and UK it is available for inhibition of labour between 24-33 weeks of gestation, and may offer better benifits: risk ratio than other tocolytics
USED:-
Used to delay imminent preterm birth in pregnant adult women displaying specific clinical observations. Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used intravenously to halt premature labor.
SIDE EFFECTS:-
Injection site reaction, Headache, Nausea, Increased glucose level in blood, Decreased blood pressure, Dizziness, Hot flashes, Slow heart rate, Vomiting etc .
DOSE:- AS DIRECTION BY THE PHYSICIAN.
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