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ATOMOXETINE

 ATOMOXETINE


BRAND NAME:- ATTENTROL 10,18,25,40mg caps AXEPTA 18,25mg caps .



ATOMOXETINE is unrelated to Tricyclic antidepressant, but is a selective NA reuptake inhibitor . It is approved only for treatment of attention deficit hyperactivity disorder (ADHD). 


PHARMACOLOGICAL & MECHANISM OF ACTION:-

This is a selective NA reuptake inhibitor, unrelated to Amphetamine as well as to imipramine, which does not enhance DA release in the brain,and is neither a CNS stimulant nor an antidepressant. However,it has been found to improve attention span and behaviour in ADHD . It is indicated in children > 6 years and in adults with concentration and attention problems.

  ATOMOXETINE is absorbed orally, hydroxylated by CYP2D6 and excreted in urine, mainly as glucuronide. While majority of individuals are extensive metabolizers (EM) ,few are poor Metabolizers (PM) due to polymorphism of CYP2D4 inhibitors of CYP2D6 like fluoxetine ,paroxetine, quinidine increase concentration and toxicity of ATOMOXETINE . It should not be given with MAO inhibitors and is contraindicated in Glaucoma.


USE:-

Atomoxetine is used to treat attention deficit hyperactivity disorder (ADHD).

Atomoxetine may also be used for purposes not listed in this medication guide .



SIDE EFFECTS:-

Atomoxetine is relatively well tolerated,does not produce agitation, seizures,dependence or arrhythmias.

Common side effects is dyspepsia, anorexia and other abdominal symptoms.

Others sleep disturbances,mood swings, emotional liability, rarely suicidal thoughts and hepatotoxicity .

GROWTH RETARDATION IS POSSIBLE IN CHILDREN.


DOSE:- 0.5mg/kg/day in the morning,may be increased upto 1.2mg/kg/day and split into morning and afternoon doses.


Adult 40mg OD , Max 100 mg / day.



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