Skip to main content

ATOMOXETINE

 ATOMOXETINE


BRAND NAME:- ATTENTROL 10,18,25,40mg caps AXEPTA 18,25mg caps .



ATOMOXETINE is unrelated to Tricyclic antidepressant, but is a selective NA reuptake inhibitor . It is approved only for treatment of attention deficit hyperactivity disorder (ADHD). 


PHARMACOLOGICAL & MECHANISM OF ACTION:-

This is a selective NA reuptake inhibitor, unrelated to Amphetamine as well as to imipramine, which does not enhance DA release in the brain,and is neither a CNS stimulant nor an antidepressant. However,it has been found to improve attention span and behaviour in ADHD . It is indicated in children > 6 years and in adults with concentration and attention problems.

  ATOMOXETINE is absorbed orally, hydroxylated by CYP2D6 and excreted in urine, mainly as glucuronide. While majority of individuals are extensive metabolizers (EM) ,few are poor Metabolizers (PM) due to polymorphism of CYP2D4 inhibitors of CYP2D6 like fluoxetine ,paroxetine, quinidine increase concentration and toxicity of ATOMOXETINE . It should not be given with MAO inhibitors and is contraindicated in Glaucoma.


USE:-

Atomoxetine is used to treat attention deficit hyperactivity disorder (ADHD).

Atomoxetine may also be used for purposes not listed in this medication guide .



SIDE EFFECTS:-

Atomoxetine is relatively well tolerated,does not produce agitation, seizures,dependence or arrhythmias.

Common side effects is dyspepsia, anorexia and other abdominal symptoms.

Others sleep disturbances,mood swings, emotional liability, rarely suicidal thoughts and hepatotoxicity .

GROWTH RETARDATION IS POSSIBLE IN CHILDREN.


DOSE:- 0.5mg/kg/day in the morning,may be increased upto 1.2mg/kg/day and split into morning and afternoon doses.


Adult 40mg OD , Max 100 mg / day.



Labels:

Comments

Post a Comment

Popular posts from this blog

BENDROFLUMETHIAZIDE Uses, Side Effects, and More

 BENDROFLUMETHIAZIDE Brand name:- Bendrofulazide, Aprinox. BENDROFLUMETHIAZIDE is a type of medicine called a diuretic. It's used to treat high blood pressure (hypertension) and the build-up of fluid in your body (oedema). Diuretics are sometimes called "water tablets" because they make you pee more. This helps get rid of extra fluid in your body. Bendroflumethiazide is only available on prescription. It usually comes as tablets. It can also come as a liquid you swallow, but this has to be specially ordered.  PHARMACODYNAMIC:-  Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessari...
Post a Comment
Read more

CLOMIPHENE CITRATE Uses, Side Effects, and More

 CLOMIPHENE CITRATE BRAND NAME:- CLOMIPHENE, FERTOMED, CLOFERT, CLOME 25,50,100mg tab.  Clomiphene is a selective estrogen receptor modulator (SERM) which treats female infertility. It works by promoting the release of reproductive hormones. This helps stimulate the release of eggs from the ovary (ovulation). PHARMACODYANIMCS:- Clomifene (previously clomiphene) is an orally administered, non steroidal, ovulatory stimulant that acts as a selective estrogen receptor modulator (SERM). Clomifene can lead to multiple ovulation, and hence increase the risk of conceiving twins. In comparison to purified FSH, the rate of ovarian hyperstimulation syndrome is low. There may be an increased risk of ovarian cancer and weight gain. Clomifene is capable of interacting with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix. It may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracel...
Post a Comment
Read more

Carbidopa Uses, Side Effects, and More

 Carbidopa Brand name:- lodosyn.  Carbidopa is always given with levodopa. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting. Pharmacodynamic:-  When mixed with levodopa, carbidopa inhibits the peripheral conversion of levodopa to dopamine and the decarboxylation of oxitriptan to serotonin by aromatic L-amino acid decarboxylase. This results in an increased amount of levodopa and oxitriptan available for transport to the central nervous system. Carbidopa also inhibits the metabolism of levodopa in the GI tract, thus, increasing the bioavailability of levodopa. The presence of additional units of circulating levodopa can increase the effectiveness of the still functional dopaminergic neurons and it has been shown to alleviate symptoms for a time. The action of carbidopa is very important as levodopa is able to cross the blood-brain barrier while dopamine cannot...
Post a Comment
Read more