Skip to main content

ATOMOXETINE

 ATOMOXETINE


BRAND NAME:- ATTENTROL 10,18,25,40mg caps AXEPTA 18,25mg caps .



ATOMOXETINE is unrelated to Tricyclic antidepressant, but is a selective NA reuptake inhibitor . It is approved only for treatment of attention deficit hyperactivity disorder (ADHD). 


PHARMACOLOGICAL & MECHANISM OF ACTION:-

This is a selective NA reuptake inhibitor, unrelated to Amphetamine as well as to imipramine, which does not enhance DA release in the brain,and is neither a CNS stimulant nor an antidepressant. However,it has been found to improve attention span and behaviour in ADHD . It is indicated in children > 6 years and in adults with concentration and attention problems.

  ATOMOXETINE is absorbed orally, hydroxylated by CYP2D6 and excreted in urine, mainly as glucuronide. While majority of individuals are extensive metabolizers (EM) ,few are poor Metabolizers (PM) due to polymorphism of CYP2D4 inhibitors of CYP2D6 like fluoxetine ,paroxetine, quinidine increase concentration and toxicity of ATOMOXETINE . It should not be given with MAO inhibitors and is contraindicated in Glaucoma.


USE:-

Atomoxetine is used to treat attention deficit hyperactivity disorder (ADHD).

Atomoxetine may also be used for purposes not listed in this medication guide .



SIDE EFFECTS:-

Atomoxetine is relatively well tolerated,does not produce agitation, seizures,dependence or arrhythmias.

Common side effects is dyspepsia, anorexia and other abdominal symptoms.

Others sleep disturbances,mood swings, emotional liability, rarely suicidal thoughts and hepatotoxicity .

GROWTH RETARDATION IS POSSIBLE IN CHILDREN.


DOSE:- 0.5mg/kg/day in the morning,may be increased upto 1.2mg/kg/day and split into morning and afternoon doses.


Adult 40mg OD , Max 100 mg / day.



Labels

Labels:

Comments

Post a Comment

Popular posts from this blog

BOTULINUM TOXIN Uses, Side Effects, and More

 BOTULINUM TOXIN ( A or B ) BRAND NAME:- BOTOX ,DYSPORT  BOTULINUM TOXIN  A and B are highly potent exotoxins produced by Clostridium botulinum that are responsible for ' botulism' ( a type of food poisoning). These neurotoxic proteins cause long- lasting loss of cholinergic transmission by interacting with axonal proteins involved in exocytotic release of Ach. Localized injection of minute quantity of botulinum toxin.  PHARMACODYNAMIC :- Botulinum toxin A inhibits the release of acetylcholine, relieving muscle contraction and spasm associated with many conditions, such as incontinence and dystonia. Cosmetically, botulinum toxin A paralyses muscles in the face to temporarily treat wrinkles. The maximum effects of muscle paralysis occur four to seven days after a dose.When injected at therapeutic doses, botulinum toxin A causes partial chemical denervation of muscle tissue, causing local reduction of muscle activity. Muscle atrophy may result, axonal sprouting may beg...
Post a Comment
Read more

Clonazepam used, Side effects, Dose, & more

Clonazepam  Brand name:- Lonazepam , Clonapax , Rivotril 0.5, 1.0, 2.0 mg tab. Clonazepam is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain. Pharmacodynamic:- The pharmacodynamic properties of clonazepam are common among benzodiazepines and include anticonvulsive, sedative, muscle relaxing and anxiolytic effects . Animal data and electroencephalographic investigations in man have shown that clonazepam rapidly suppresses many types of paroxysmal activity including the spike and wave discharge in absence seizures (petit mal), slow spike wave, generalized spike wave, spikes with temporal or other locations, as well as irregular spikes and waves Label . Moreover, the agent can also decrease the frequency, amplitude, duration, and spread of discharge in minor motor seizures Label . Generalized EEG abnormalities are more readily suppressed by clonazepam than are focal ...
Post a Comment
Read more

CLOMIPHENE CITRATE Uses, Side Effects, and More

 CLOMIPHENE CITRATE BRAND NAME:- CLOMIPHENE, FERTOMED, CLOFERT, CLOME 25,50,100mg tab.  Clomiphene is a selective estrogen receptor modulator (SERM) which treats female infertility. It works by promoting the release of reproductive hormones. This helps stimulate the release of eggs from the ovary (ovulation). PHARMACODYANIMCS:- Clomifene (previously clomiphene) is an orally administered, non steroidal, ovulatory stimulant that acts as a selective estrogen receptor modulator (SERM). Clomifene can lead to multiple ovulation, and hence increase the risk of conceiving twins. In comparison to purified FSH, the rate of ovarian hyperstimulation syndrome is low. There may be an increased risk of ovarian cancer and weight gain. Clomifene is capable of interacting with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix. It may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracel...
Post a Comment
Read more