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ARTEROLANE MALEATE

 ARTEROLANE MALEATE 


BRAND NAME:- no specific brand in single composition.



ARTEROLANE, also known as OZ277 or RBx 11160, is a substance that was tested for antimalarial activity. Its molecular structure is uncommon for pharmacological compounds in that it has both an ozonide (trioxolane) group and an adamantane substituent.

      

MECHANISM & PHARMACOLOGICAL ACTION:-   

ARTEROLANE acts rapidly at all stages of asexual schizogony  of malarial parasite including multidrug resistant P.f.,but has no effect on the hepatic stages. It accumulates in the food vacuole of the parasite,and thus differs from artemisinins which do not accumulates at this site. It also has moderate gametocidal activity similar to that of artemether - LUMEFANTRINE . 

Arterolane are well absorbed orally, and absorption is unaffected by food. Peak plasma arterolane concentration is reached 3-5 hours and it has a large volume of distribution . The major metabolic pathway is oxidation,Mainly  by CYP3A4 , which is also the primary ISOENZYME responsible for PIPERAQUINE metabolism . Arterolane is short acting and it's plasma t½ varies between 1-3 hours.


(It is a artemisinin based combination Therapy (ACT )  regimens for Uncomplicated falciparum malaria . )


IN  2012, RANBAXY OBTAINED APPROVAL TO MARKET THE ARTEROLANE/PIPERAQUINE COMBINATION DRUG IN INDIA, UNDER THE BRAND NAME SYNRIAM 


USED:- treatment of malaria 🦟.


SIDE EFFECTS:- 

mild headache, dizziness, vomiting, nausea, abdominal pain etc.


DOSE:- DIRECTION BY PHYSICIAN.

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