Skip to main content

ARTEROLANE - PIPERAQUINE

 ARTEROLANE+ PIPERAQUINE



BRAND NAME:- Synriam ( arterolane malate 150mg + piperaquine 750mg ) 



ARTEROLANE MALEATE+PIPERAQUINE PHOSPHATE together treats malaria. They work by increasing the levels of heme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading.

       ARTEROLANE - PIPERAQUINE FDC has undergone multicentric clinical trials in India 🇮🇳, Bangladesh and Thailand. In uncomplicated falciparum malaria 🦟 this ACT has produced ≥ 95% cure rates with a fever and parasitaemia  clearance time 24-28 hours. In a comparative trail its efficacy and tolerability has been found equivalent to artemether - LUMEFANTRINE. 


Thus arterolane - piperaquine appears to be an effective and well tolerated alternative ACT. 


 

USED:- treatment of malaria 🦟.



SIDE EFFECTS:-  are generally mild headache, postural dizziness, vomiting, abdominal pain and Diarrhoea.



DOSE:- 1 CAP. OD for 3 days.






Comments

Popular posts from this blog

BENDROFLUMETHIAZIDE Uses, Side Effects, and More

 BENDROFLUMETHIAZIDE Brand name:- Bendrofulazide, Aprinox. BENDROFLUMETHIAZIDE is a type of medicine called a diuretic. It's used to treat high blood pressure (hypertension) and the build-up of fluid in your body (oedema). Diuretics are sometimes called "water tablets" because they make you pee more. This helps get rid of extra fluid in your body. Bendroflumethiazide is only available on prescription. It usually comes as tablets. It can also come as a liquid you swallow, but this has to be specially ordered.  PHARMACODYNAMIC:-  Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessari...

CLOMIPHENE CITRATE Uses, Side Effects, and More

 CLOMIPHENE CITRATE BRAND NAME:- CLOMIPHENE, FERTOMED, CLOFERT, CLOME 25,50,100mg tab.  Clomiphene is a selective estrogen receptor modulator (SERM) which treats female infertility. It works by promoting the release of reproductive hormones. This helps stimulate the release of eggs from the ovary (ovulation). PHARMACODYANIMCS:- Clomifene (previously clomiphene) is an orally administered, non steroidal, ovulatory stimulant that acts as a selective estrogen receptor modulator (SERM). Clomifene can lead to multiple ovulation, and hence increase the risk of conceiving twins. In comparison to purified FSH, the rate of ovarian hyperstimulation syndrome is low. There may be an increased risk of ovarian cancer and weight gain. Clomifene is capable of interacting with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix. It may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracel...

Carbidopa Uses, Side Effects, and More

 Carbidopa Brand name:- lodosyn.  Carbidopa is always given with levodopa. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting. Pharmacodynamic:-  When mixed with levodopa, carbidopa inhibits the peripheral conversion of levodopa to dopamine and the decarboxylation of oxitriptan to serotonin by aromatic L-amino acid decarboxylase. This results in an increased amount of levodopa and oxitriptan available for transport to the central nervous system. Carbidopa also inhibits the metabolism of levodopa in the GI tract, thus, increasing the bioavailability of levodopa. The presence of additional units of circulating levodopa can increase the effectiveness of the still functional dopaminergic neurons and it has been shown to alleviate symptoms for a time. The action of carbidopa is very important as levodopa is able to cross the blood-brain barrier while dopamine cannot...