ARGATROBAN

 ARGATROBAN

BRAND NAME:- no specific brand available.

ARGATROBAN is a synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use.

PHARMACOLOGICAL ACTION:-

Argatroban is a synthetic nonpeptide compound which binds reversibly to the catalytic site of thrombin,but not to the substrate recognition site. As such ,it produces a rapid and short lasting antithrombin action .That is approved in the USA, the EU and Japan for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT), and for anticoagulation of HIT patients undergoing PCI. 

MECHANISM OF ACTION:-

Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; protein C; and platelet aggregation. Administered by i.v . Infusion,it can be used in place of lepirudin for short - term indication in patients with heparin-induced thrombocytopenia.

USE:- 

Argatroban is a medication used to manage heparin-induced thrombocytopenia (HIT), which is a rare, life-threatening complication of heparin therapy. It is a direct thrombin inhibitor, a class of anticoagulant drugs.

SIDE EFFECTS:- 

Common side effect nausea,vomiting,diarrhea,stomach pain,fever,headache,back pain, minor bleeding or irritation at the injection site.

DOSE :- DIRECT BY PHYSICIAN