ARGATROBAN
BRAND NAME:- no specific brand available.
ARGATROBAN is a synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use.
PHARMACOLOGICAL ACTION:-
Argatroban is a synthetic nonpeptide compound which binds reversibly to the catalytic site of thrombin,but not to the substrate recognition site. As such ,it produces a rapid and short lasting antithrombin action .That is approved in the USA, the EU and Japan for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT), and for anticoagulation of HIT patients undergoing PCI.
MECHANISM OF ACTION:-
Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; protein C; and platelet aggregation. Administered by i.v . Infusion,it can be used in place of lepirudin for short - term indication in patients with heparin-induced thrombocytopenia.
USE:-
Argatroban is a medication used to manage heparin-induced thrombocytopenia (HIT), which is a rare, life-threatening complication of heparin therapy. It is a direct thrombin inhibitor, a class of anticoagulant drugs.
SIDE EFFECTS:-
Common side effect nausea,vomiting,diarrhea,stomach pain,fever,headache,back pain, minor bleeding or irritation at the injection site.
DOSE :- DIRECT BY PHYSICIAN
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