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ARDEPARIN

 ARDEPARIN


BRAND NAME:- INDEPARIN 2500 IU ,5000 IU Prefilled syringes .



ARDEPARIN is a low molecular weight (LMW) anticoagulant used for the prevention of postoperative venous thrombosis.Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight of 5500 to 6500.



PHARMACODYNAMIC:- 


Ardeparin, an anticoagulant, is a fractionated heparin. It acts at multiple sites in the normal coagulation system to inhibit reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. 


MECHANISM OF ACTION:-


Ardeparin has been fractionated into LMW forms (MW 3000-7000) by different anticoagulants profile; i.e. selectively inhibits factor Xa with little effect on IIa. Ardeparin binds to antithrombin III, accelerating its activity in inactivating factor Xa and thrombin, thereby inhibiting thrombosis. Ardeparin also binds to heparin cofactor II, inhibiting thrombin. Ardeparin does not effect prothrombin time (PT) assays and may prolong activated partial thromboplastin time (APTT). Ardeparin has double the anti-factor Xa activity versus anti-factor IIa activity, compared to unfractionated heparin which has approximately equal anti-factor Xa activity and anti-factor IIa activity.


USED:- 

IN treatment of established deep vein thrombosis . Ardeparin is used to prevent Acute coronary syndrome, Pulmonary embolism. It prevents the formation of blood clots in the legs, lungs, brain or heart.


DOSE:- 2500- 5000 IU OD 


SIDE effects:-

Common side effects  are bleeding, Injection site reaction or etc.





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